Hermetic Breakthroughs

Really simple question: Where are the rules for hermetic breakthroughs detailed? Specifically, altering virtues for a laboratory?

I know there are rules for integrating stuff into Hermetic Theory in Ancient Magic, but that's not entirely what I'm looking for. Are the rules detailed somewhere? Or is it just adapting what's in Ancient Magic and winging it?

Look up HoH:TL p.26ff Original Research. AM p.7f The Breakthrough refers in terminology and content to HoH:TL.