I just asked basically the same question here... https://forum.atlas-games.com/t/lunch-money-beer-money-general-rules-question-on-defense/3035/1
... as our group generally assumes "You had a chance to defend, it was Humiliated, can't throw another Defense card."
I'm ok with "only one chance to respond to an attack" but the rules don't specifically state one way or another. I came to the forums just wondering about this.
Like what about this scenario:
Player 1 plays a Grab
Player 2 defends with a Dodge
Player 3 Humiliates the Dodge so that the Grab goes through.
Player 1 plays Power Play, then Smite w/Weird on it.
Player 2 then defends with Backlash which reverses the combo onto Player 1.
Player 3 then gets their free basic attack on Player 1.
See... I think the above should be allowed... essentially even though the Dodge was Humiliated, Player 2 could still use Backlash. My group would say, "No, you had your defense chance with Dodge and it was Humiliated. You don't get a second chance."
As long as your group is consistent, I see no problem with either interpretation... but since the rules don't forbid multiple defense cards in response, I think it should be allowed.
Thoughts?