Alchemycal Reagents and Elementals

I was seeing A&A and then i thougt: Would be one matter worked by human hands purified by one reactive reagent? Would be possible transform after that effect the matter to be one elemental? Would be a fire elemental bringed about one alchemycal fire or one purified fire?
I can imagine than the water, soil, earth and rocks would be easilier purified (Alteration: Minor) than fire or air (Substantial), and would be easier or harder the magically created?