There is a good chance as others have said, it all blows over, however, if you want it as a story hook, personalities matter.
It only take a few high profile people to get angry for stuff to get serious. I don't have the relevant book to hand, however, if I recall correctly the Schism War ended with a big epic spell by some Guernicus magi, based on some scrolls that the founder had put aside to be used in dire emergencies. I think blood magic was involved.
All it takes is a few Guernicus magi to start demanding apologies and reparations. These forgeries make a mockery of them and everything they and their founder held dear when they were used to justify destroying Diedne.
The surviving Diedne reveal themselves to Guernicus, saying they will help if Tremere and Tytalus don't pay up. Power up the Diedne with a bit of non-hermetic curses which are more powerful than they should be due to being wronged for centuries, you've got a potent starting point.
Tremere and Tytalus are generally seen as the least trusted in the order. We all know Tremere want one united order with Tremere as leader, and the sundering was just a set back. Tytalus's desire for conflict just annoys everyone.
Tremere know Tytalus won't tolerate saying sorry and paying reparations. If Guernicus and Diedne are smart they demand reparations Tytalus and Tremere won't accept, however, they have a secret agreement that after Tremere help in destroying Tytalus, they'll tone the reparations down as thanks for all their help in taking down Tytalus. Tremere will do near anything to avoid the whole order hunting them down.
You can also have Guernicus and Diedne getting everyone on board to bring down Tremere.
They could get the whole order to go after Tremere and Tytalus. While it is trickier going after 2 houses at once, I can't see Tremere and Tytalus helping each other.
There's a bunch of story options such a potent trigger event can kick off.