I like all nearly all the new Houses. Never got to play one for more than a few sessions, though. It's hard to choose one.
My favorite house probably remains Criamon. I like their newfound wacko theories, I think they provide a nice focus and areas of interest. I like playing fairly orthodox new Criamon, except perhaps for the pacifistic part and that I find it hard to limit my spellcasting.
I also like to play the "pagan revivalist", which fits well with True Merinitia or Huntress in the Woods Bjornaer; I don't really like either House Merinitia or House Bjornaer as a whole, though. I just don't like the faeries, so no Merinitia. And while Bjornaer is far better than it was, I still find it kinda confused and aimless - animal ancestors?! With some tweaks, seeing Bjornaer as a mystery cult of "shapeshifters" that sees their true nature as beings of magic rather than mere humans, I could play a Bjornaer happily - but this is a far distance from the House as written. House Ex Misc also serves well for a rivavalist, and I appreciate the new extensive rules, but otherwise I don't find the House changed much.
I'd also like to play a Jerbiton serving as a knight of Nicea (the Code be damned), trying to restore it to its rightful place and put history back on track. I liked the new focus on the City and Eastern culture. But this is a very specific role fit for a very specific campaign, and I can't seem to pull off politics very well.
These are probably my favorites. I also liked how Tremere was depicated but find them a little hard to run (no focus or vote, lots of house-specific politics...), and how Tytalus was explained (really adds depth to their roleplaying). I mostly like the other Houses better than the old ones, but they're just not my favorites.
I didn't like the new Verditius' hubris (I see it as highly limiting their character), or that mundane vandettas matter in their history. It is probably my least favorite house as written, because of this, even though it has some great bits. I also don't like Bjornaer's ancestor-worship, or its myriad subdivisions, making it my second last choice as written - again, despite excellent ideas on the House, its history, the mysteries, and so on.